Synthesis of novel fluorous reagents for synthesis: Fluorous-TEMPO and Fluorous-DMPU

ORGN 738

Mark J. Penny, m.j.penny@qmul.ac.uk1, Adrian P. Dobbs1, and Peter Jones, Peter.Jones2@pfizer.com2. (1) School of Biological and Chemical Sciences, Queen Mary, University of London, Walter Besant Building, Mile End Road, London, E1 4NS, United Kingdom, (2) Discovery Chemistry, Pfizer Global R&D, Sandwich, Kent, CT13 9NJ, United Kingdom
Fluorous reagents are becoming increasingly popular as alternative reagents for synthesis, owing to their ease of use and subsequent removal and separation/purification from reactions, either by fluorous liquid-liquid extraction or fluorous silica-based solid-liquid separation.

We herein report the synthesis and applications of two novel fluorous reagents: a stable radical, fluorous-TEMPO and a potential HMPA-replacement, fluorous-DMPU.

 

Combinatorial, Parallel and Process Chemistry, Heterocycles, Aromatics, New Reactions and Methodology
8:00 PM-10:00 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Organic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007