Synthesis and characterization of new photosensitizers for photodynamic therapy

ORGN 492

David S Crumrine, dcrumri@luc.edu, Prakash B. Sanjeevaiah, psanjee@luc.edu, and Basel M Zaitoun, bzaitou@luc.edu. Department of Chemistry, Loyola University Chicago, 6525 N. Sheridan Rd, chicago, IL 60626
Photodynamic Therapy (PDT), an anticancer treatment that utilizes a photosensitizer, light and oxygen, continues to be an exciting area. Phenothiazine derived and halogenated Squarine dye derived photosensitizers (shown below) are ideal candidates for PDT because they have: intense visible absorptions; high intersystem crossing efficiencies; ease of modification; biodegradability etc. Treatment efficacy should be increased by linking the sensitizer to a cell recognition probe. Synthesis, spectroscopic and biochemical characterization of some of these promising agents will be discussed.

 

Physical Organic Chemistry, Metal-Mediated Reactions, Asymmetric Reactions and Syntheses
8:00 PM-10:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Organic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007