Synthesis of Isochroman-based small molecule libraries

ORGN 820

Bo Leng, lengboxi@bu.edu1, Aaron B. Beeler, beelera@chem.bu.edu2, and John A. Porco Jr., porco@bu.edu2. (1) Department of Chemistry, Center for Chemical Methodology and Library Development at Boston University, 24 Cummington Street Rm 828, Boston, MA 02215, (2) Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU), Boston University, MA
The synthesis of isochroman core structures has been developed utilizing alkynyl benzaldehydes, malonates, and Rh(I) catalysis. Application of the methodology to prepare an isochroman library will be described.

 

Combinatorial, Parallel and Process Chemistry, Heterocycles, Aromatics, New Reactions and Methodology
8:00 PM-10:00 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Organic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007