ORGN 807 |
| Compound libraries generated by parallel synthesis often suffer from either insufficient diversity, such that all compounds are nearly identical, or too much diversity, so that hit verification can be time consuming and costly. These libraries respectively risk missing potentially valuable hits outside of a narrowly defined compound space, or risk identification of false positives where expensive follow-up studies are fruitless. Our research has focused on addressing these problems through the design of libraries that incorporate both wide diversity and also clusters of sufficiently similar compounds to allow immediate hit verification. Through the course of this research we have identified methods to balance the desire to maximize the utility of these libraries while keeping the chemical synthesis requirements reasonable. Due to the inherent diversity of the libraries, some unexpected synthesis and purification challenges were encountered and then overcome using a variety of standard and novel approaches.
|
|
Combinatorial, Parallel and Process Chemistry, Heterocycles, Aromatics, New Reactions and Methodology
8:00 PM-10:00 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Organic Chemistry |
