ORGN 934 |
| The development and the kilogram-scale synthesis of a spirocyclic hydantoin Drug Candidate (1) will be presented. The key transformation in the synthesis is a [3+2] cycloaddition to install the spirocyclic center. Compound 1 was efficiently prepared in only 4 steps in an overall yield of 22%.
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Heterocycles and Aromatics
8:00 AM-12:00 PM, Thursday, August 23, 2007 BCEC -- 254 A/B, Oral
Division of Organic Chemistry |
