ORGN 780 |
| The construction of the trans-hydrindane portion of steroids, vitamin D, higher terpenes and related natural products has been a long-standing challenge in synthetic organic chemistry. Catalytic hydrogenation of hydrindenes has appeared to be a convenient approach for the creation of the hydrindane system. However, there have been conflicting reports on the stereochemical outcomes of hydrindanes via catalytic hydrogenation of hydrindenes. We will present the study of catalytic hydrogenation of hydrindenes with an oxygen-containing side-chain on the enone system, as well as structural elucidation of the stereochemistry by X-ray crystallography. On the basis of construction of both cis- and trans-O-alkylated-hydrindanes, stereoselective synthesis of cis- and trans-7-oxa-estra-4,9-diene-3,17-diones will be discussed. |
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Combinatorial, Parallel and Process Chemistry, Heterocycles, Aromatics, New Reactions and Methodology
8:00 PM-10:00 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Organic Chemistry |