Pd-catalyzed aryl amination of purine nucleosides

ORGN 552

Paul F. Thomson, paulfthomson@gmail.com, Pallavi Lagisetty, pollapallavi@yahoo.com, and Mahesh K. Lakshman, lakshman@sci.ccny.cuny.edu. Department of Chemistry, The City College and The City University of New York, 138th Street at Convent Avenue, New York, NY 10031
Palladium-catalyzed C-N bond formation is an invaluable tool for coupling aryl halides and amines. This work aims to understand the differences in amination reactions of halo purine (chloro and bromo) nucleosides and herein we report our findings on optimal conditions for activation of the halo nucleosides as well as protecting group influences on the reactions. Using the knowledge gained, biologically important nucleoside derivatives have been synthesized.

 

Physical Organic Chemistry, Metal-Mediated Reactions, Asymmetric Reactions and Syntheses
8:00 PM-10:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Organic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007