Cross-bridged tetraazamacrocycles bearing phosphonate and phosphonic acid pendant arms and their Cu(II) complexes

ORGN 754

Dannon J Stigers, dstigers@cisunix.unh.edu1, Gary R. Weisman, gary.weisman@unh.edu1, Edward H. Wong, ehw@unh.edu1, and Carolyn J. Anderson, andersoncj@wustl.edu2. (1) Department of Chemistry, University of New Hampshire, Durham, NH 03820, (2) Division of Radiological Sciences, Washington University School of Medicine, St. Louis, MO 63110
Metal complexes of cross-bridged tetraamines bearing ionizable pendant arms have shown increased kinetic inertness towards decomplexation over their non-bridged analogues, making them attractive radiopharmaceutical agents. Two cross-bridged tetraamines have been appended with phosphonate pendant arms. Acid or base hydrolysis yields fully hydrolyzed or partially hydrolyzed phosphonates respectively. The Cu(II) complexes of these ligand have been synthesized and characterized.

 

Combinatorial, Parallel and Process Chemistry, Heterocycles, Aromatics, New Reactions and Methodology
8:00 PM-10:00 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Organic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007