ORGN 744 |
| Beta-amino ketones and their derivatives are very attractive compounds because of their medicinal properties. Therefore, the development of new catalytic methods for their preparation is of considerable importance in organic synthesis. We have reported the use of bismuth nitrate in several organic transformations. Bismuth nitrate has attracted attention due to its low toxicity, low cost and high stability. During the course of the study, we develop a new pathway for the synthesis of beta amino ketones through bismuth nitrate-catalyzed reaction. The reaction of various amines with two carbonyl compounds in the presence of catalytic amounts of bismuth nitrate produced beta amino ketones along with some unidentified products. Notably this method has become successful with unmodified carbonyl compounds and therefore, this method does not require prior isolation of the imines. Although the precise mechanism has not been elucidated, this success might be due to nitric acid released from hydrolysis of bismuth nitrate pentahydrate. However, the reaction has failed to produce any desired products in the presence of water and bismuth nitrate. |
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Combinatorial, Parallel and Process Chemistry, Heterocycles, Aromatics, New Reactions and Methodology
8:00 PM-10:00 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Organic Chemistry |