ORGN 769 |
| Abstract A new route for preparing porphyrins that bear up to four different meso-substituents (ABCD-porphyrins) has been developed. The route relies on the preparation of a 1-acyl-19-X bilane (1), which is derived from two dipyrromethane species. A lengthy study of suitable X groups, methods for stepwise conversion of 1 to the ABCD-porphyrin 2, and conditions for the latter transformation have been examined. A one-flask transformation also has been identified that gives the ABCD-porphyrin 2 from 1 in 65% yield.
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Combinatorial, Parallel and Process Chemistry, Heterocycles, Aromatics, New Reactions and Methodology
8:00 PM-10:00 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Organic Chemistry |
