ORGN 814

Process for the preparation of a ketolide antibiotic

Timothy B. Towne, tim.towne@abbott.com¹, Daniel S. Reno, dreno@endocyte.com¹, Deborah A. Davis, Deborah.Davis@abbott.com¹, Steven J. Wittenberger, Jianzhang Mei, jianzhang.mei@abbott.com¹, Shyamal Parekh¹, Marius Naris², and Eric Kristensen². (1) GPRD Process Chemistry, Abbott Laboratories, 1401 Sheridan Road, North Chicago, IL 60064, (2) GPRD Analytical Process Research and Development, Abbott Laboratories, 1401 Sheridan Rd, North Chicago, IL 60064

Multi-gram quantities of 1, an Erythromycin A derived ketolide antibiotic, were needed for pre-clinical evaluation. The title compound was prepared in five chemical transformations from the cyclic carbamate 2. Initial route selection and laboratory scale-up will be presented.

Combinatorial, Parallel and Process Chemistry, Heterocycles, Aromatics, New Reactions and Methodology
8:00 PM-10:00 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Organic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007