Overcome the limitation of acyl chloride in amide bond formation and peptide coupling

ORGN 825

Li Zhang, Xiao-Jun Wang, Dhileep Krishnamurthy, and Chris Senanayake. Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc, 900 Ridgebury Rd., Ridgefield, CT 06877
Acyl chloride is a very useful reagent in the synthesis of amides and peptides. Nevertheless, the value of acyl chloride has been limited due to the possibility of hydrolysis, recemisation and other side reactions. In this presentation, a new strategy is introduced to overcome the limitation.