ORGN 643 |
| The author's transition from a “hard-core” physical-organic photochemist to a synthetic heterocyclic chemist interested in new cascade reactions for alkaloid synthesis will be discussed. Domino processes belong to a growing family of reactions which allow for the regio- and stereocontrolled formation of several carbon-carbon bonds and/or ring systems in a single operation. Application of several tandem cascade processes for the synthesis of various alkaloidal targets carried out at Emory will be discussed from a mechanistic viewpoint. Our fascination with domino cascade chemistry is based on mechanistic chemistry learned at the University of Wisconsin in the early 60's under the tutelage of HEZ. |
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Sixty Years of Physical Organic Chemistry
8:10 AM-12:00 PM, Wednesday, August 22, 2007 BCEC -- Ballroom, Oral
Division of Organic Chemistry |