ORGN 638 |
| Silica-bound isocyanate is designed as covalent scavenger for primary, secondary amines and aniline. This bounded–scavenger used in solution phase organic synthesis of urea and thiourea compounds to reduce purification bottleneck. In this technique product remain in solution, while excess amines and aniline are bounded to silica. The disadvantage of this technique is the relative slow rate of reaction. Microwave irradiation has been used to overcome this problem and increase rate of scavenging. This presentation covers utilization of microwave heating with silica-bound isocyanate as covalent scavenger for amines in rapid synthesis and purification of urea and thiourea compounds.
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Asymmetric Reactions, Combinatorial Chemistry, Molecular Recognition and Self-Assembly, Proteins, Peptides, Amino Acids and Enzyme Inhibitors
8:00 PM-10:00 PM, Wednesday, March 28, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |
