ORGN 319 |
| Furans and hydrofurans are well known compounds found in the natural products and pharmaceuticals; currently the synthesis of these compounds using catalytic methods constitutes an important focus of research. Although fluorine substituted furans and hydrofurans are attractive targets from a biological standpoint, there are few reports on practical methods for preparing them, none of which is catalytic. Recently, a cost-effective synthesis of gem-difluoro homopropargyl alcohols (1) was reported by our group. Using the triple bond of gem-difluoro homopropargyl alcohols (1) as a synthetic handle, we have uncovered novel transformations toward fluorinated furans and hydrofurans.
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Heterocycles and Aromatics
8:00 AM-12:00 PM, Tuesday, March 27, 2007 McCormick Place Lakeside -- Room E350, Level 3, Oral
Division of Organic Chemistry |
