ORGN 440 |
| The creation of new materials for sensing and actuation requires careful manipulation of the responsive units required to control analyte selectivity. We have developed a series of molecular sensors based on dipyrido-[3,2-a:2'3'-c]phenazine (DPPZ). Rational choice of substituents at the 3 and 6 positions and the back-end phenazine unit of DPPZ allow manipulation of optical, electrochemical and mechanical properties required to selectively distinguish between various toxic organophosphorus-based pesticides and chemical warfare agent mimics. We have demonstrated that 3,6-dialkylbenzo[i]dipyrido-[3,2-a:2'3'-c]phenazine in comparison to benzo[i]dipyrido-[3,2-a:2'3'-c]phenazine show significant differences in the optical and electrochemical signal outputs upon interaction with various organophosphorus compounds including diethyl chlorothiophosphate, diethyl chlorophosphate, dimethyl methylphosphonate, and the pesticides fenthion and paraoxon. The presentation will demonstrate the rational choices in substituent selection for selective discrimination between organophosphorus compounds. |
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New Reactions and Methodology, Total Synthesis, Materials, Devices and Switches, Lipids, Nucleotides and Mimetics
8:00 PM-10:00 PM, Tuesday, March 27, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |