Dynamics of metal transport across a liquid membrane mediated by self-assembled ionophores

ORGN 706

Mariana Martin-Hidalgo, pincelita@hotmail.com1, Karla Camacho-Soto2, Vladimir Gubala, gubala@adam.uprr.pr2, and José M. Rivera, jrivera@cnnet.upr.edu2. (1) Department of Chemistry, University of Puerto Rico, San Juan, PR 00725, (2) Department of Chemistry, University of Puerto Rico at Río Piedras, PO Box 23346, San Juan, PR 00931-3346
We have developed 8-aryl-2'-deoxyguanosine (8ArG) derivatives that serve as monomers to construct self-assembled ionophores. Four monomers form a tetrad and two or more tetrads form a quadruplex templated by a metal cation. Quantitative transport data for metal picrates was gathered with derivatives mAGi, pAGi, Gi and 18-Crown-6 (18C6) as ionophores. Approximate values for the extraction constants (kex) of these ligands were estimated using a simple model system (Fyles et al. 1987). In fact, our ligands seem to be better transporters over longer periods of times (> 2 hrs) than the well-studied ionophore 18C6. These results demonstrate that our ligands seem to be better transporters in long term results than the well-studied ionophore 18C6. New and efficient self-assembled transporters can be used in environmental separations, and drug delivery.

 

Asymmetric Reactions, Combinatorial Chemistry, Molecular Recognition and Self-Assembly, Proteins, Peptides, Amino Acids and Enzyme Inhibitors
8:00 PM-10:00 PM, Wednesday, March 28, 2007 Hyatt Regency Chicago -- Riverside Center, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, March 26, 2007 Hyatt Regency Chicago -- Riverside Center, Sci-Mix

Division of Organic Chemistry

The 233rd ACS National Meeting, Chicago, IL, March 25-29, 2007