ORGN 402 |
| Azaspirene, a member of the pseurotin family, is a novel angiogenesis inhibitor. It has biological activity that treats angiogenesis-related diseases such as cancer and rheumatoid arthritis. We have been investigating the total synthesis of azaspirene, aiming to achieve a concise stereocontrolled route to this unique anti-cancer agent as well as a library thereof. New methodology developed in our lab is invented in the synthetic route toward Azaspirene; the direct conjugate addition of alkenylzirconocene and alkenylzincate reagents employing copper(I) catalysis. Other key reactions are utilized such as SADH, RCM and peptide coupling of easily available intermediates to build one advanced fragment. Our overall synthetic strategy is of a great economical use compared to few other reported synthetic studies toward the target molecule. The ultimate goal with the proposed approach is the development of new methodologies in organic synthetic chemistry applied toward building important drugs to battle cancer.
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New Reactions and Methodology, Total Synthesis, Materials, Devices and Switches, Lipids, Nucleotides and Mimetics
8:00 PM-10:00 PM, Tuesday, March 27, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |
