ORGN 409 |
| Pleuromutilin – isolated in 1951 from Pleurotus mutilus – has given rise to a number of very potent antibacterial derivatives, among which are tiamulin (currently used in veterinary medicine) and retapamulin (recently approved for FDA review for use in human therapy). The biological importance of pleuromutilin derivatives along with their intriguing tricyclic core has motivated us to pursue a synthesis of the parent molecule. We are investigating a highly practical approach that utilizes gold-catalyzed enyne cycloisomerization, a reaction recently developed in our group.
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New Reactions and Methodology, Total Synthesis, Materials, Devices and Switches, Lipids, Nucleotides and Mimetics
8:00 PM-10:00 PM, Tuesday, March 27, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |
