Synthesis and characterization of glycolipids as novel hydrogelators

ORGN 704

Sherwin Cheuk, sycheuk@uno.edu, Branden Hopkinson, bmhopkin@uno.edu, and Guijun Wang, gwang2@uno.edu. Department of Chemistry, University of New Orleans, 2000 Lakeshore Drive, New Orleans, LA 70148
Low molecular weight gelators (LMWGs) are a class of molecules able to gelate solvents through noncovalent interactions. LMWGs were discovered during the past decades, the self-organizing of small molecules and their potential applications have drawn a great interests among chemists. We have developed both organo- and hydrogelators from a simple derivative of glucose, O-4,6-benzylidene-a-methyl-glucopyranoside. By selectively functionalizing the 2 or 3 positions with carbamate functionality (1, 2), we are able to obtain a new family of organogelators that can effectively gelate water or aqueous solution. These new materials are expected to be useful in drug delivery, tissue engineering, and purification of biomolecules. The synthesis and characterization of these novel organogelators and their application in enzyme immobilization will be presented.