ORGN 3 |
| Marine neurotoxins can serve as important pharmacological tools for understanding protein function associated with the highly complex ionic mechanisms of electrical transmission in cells. The voltage-gated Na+ ion channel is a primary site of action for many such poisonous substances. Among such agents, tetrodotoxin, the guanidinium poison synonymous with the Japanese puffer fish, and saxitoxin are foremost. This lecture will attempt to illustrate how synthetic chemistry and molecular design may be used to reveal the inner workings of the Na+ ion channel. |
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Ernest Guenther Award in the Chemistry of Natural Products: Symposium in Honor of Dale L. Boger
8:45 AM-11:50 AM, Sunday, March 25, 2007 McCormick Place Lakeside -- Room E450 A/B, Level 4, Oral
Division of Organic Chemistry |