ORGN 290 |
| Functionalization of C-H bonds through mild, selective methods holds tremendous potential to advance synthetic chemistry. However, to this point, few C-H activation methods have been applied to advanced and/or complicated substrates. A DMSO/Pd(II) catalyzed allylic C-H oxidation method for converting α-olefins to linear (E)-allylic esters will be presented. A general strategy for the synthesis of complex, polyoxygenated frameworks enabled by this method will be discussed. Validation of this strategy through an enantioselective total synthesis of a differentially protected L-hexose will be presented |
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Total Synthesis of Complex Molecules
1:00 PM-4:40 PM, Monday, March 26, 2007 McCormick Place East -- Room E352, Level 3, Oral
Division of Organic Chemistry |