ORGN 243 |
| Natural products and natural product analogs display a wide variety of functions in a biological context. In order to elucidate the potential behind these molecules, it is advantageous to synthesize them in a library format and subsequently evaluate them in biological assays. The solid-supported [2+2+2] cyclotrimerization provides a powerful approach towards the assembly of carbo- and heterocyclic libraries based on core structures found in nature. Here, we will report the application of cyclotrimerization reactions to the synthesis of arrays of natural product analogs, modifiers of developmental pathways, and fluorescent probes. |
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Combinatorial and Process Chemistry
8:00 AM-11:40 AM, Monday, March 26, 2007 McCormick Place East -- Room E350, Level 3, Oral
Division of Organic Chemistry |