ORGN 466 |
| Xanthene dyes can exist in two forms: open and closed. The closed form is typically colorless and non-fluorescent. The open form is colored (ranging from red to yellow) and fluorescent. Xanthene dyes can be switched from the closed to open form by changing the pH or polarity of the solution. Recent work demonstrated the unique sensing potential of an on/off rhodamine B system for the differentiation of aliphatic amines, aminoalcohols and diastereomeric aminoalcohols. The selectivity and sensitivity observed by the monitoring of fluorescence of rhodamine B has led to the development of new xanthene based systems for detection of other classes of analytes. Herein is an account of the development of rhodamine B lactams via amidization with aniline and aminopyridines. The potential to differentiate biogenic carboxylic acids will be investigated by monitoring the fluorescence of on/off rhodamine B lactams.
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New Reactions and Methodology, Total Synthesis, Materials, Devices and Switches, Lipids, Nucleotides and Mimetics
8:00 PM-10:00 PM, Tuesday, March 27, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |
