ORGN 717 |
| Allylic hydroxy phosphonates are versatile intermediates for the asymmetric synthesis of natural products and enzyme inhibitors. A variety of substituted allylic hydroxy phosphonates and the carbonate derivatives can be prepared via cross metathesis of phosphonates 1 and 2 with substituted alkenes. The stereospecific palladium catalyzed addition of oxygen nucleophiles to phosphono allylic carbonates results in the efficient stereoselective synthesis of tetrahydrofurans and pyrans; the useful nonracemic building blocks for the synthesis of biologically active molecules.
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Asymmetric Reactions, Combinatorial Chemistry, Molecular Recognition and Self-Assembly, Proteins, Peptides, Amino Acids and Enzyme Inhibitors
8:00 PM-10:00 PM, Wednesday, March 28, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |
