ORGN 294 |
| Bistramide A is a highly potent antiproliferative marine natural product. We have previously established that bistramide A targeted monomeric actin in the cell with high specificity and potency. In order to establish the binding mode of the natural product, we crystallized the complex of bistramide A bound to actin. We then employed chemical synthesis in order to establish the pharmacophore model of the natural product, resulting in the assembly of several simplified bistramide-like compounds with potent bioactivity, which will be discussed.
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Total Synthesis of Complex Molecules
1:00 PM-4:40 PM, Monday, March 26, 2007 McCormick Place East -- Room E352, Level 3, Oral
Division of Organic Chemistry |
