Progress toward the synthesis of peyssonenynes A & B

ORGN 415

Ronald V. Lerum, rvlerum@syr.edu and John D. Chisholm. Department of Chemistry, Syracuse University, 1-014 CST, 111 College Pl, Syracuse, NY 13244
DNA methyltransferase (DNMT-1) inhibitory natural products, Peyssonenyne A & B, were harvested from a Fujian red marine alga Peyssonnelia caulifera. The use of Peyssonenynes A & B in regulating DNMT-1 can potentially be an effective tool towards reversing tumor growth. Both compounds have a novel enol acetate-containing enediyne motif. Progress towards the stereoselective synthesis of Peyssonenynes A & B will be presented.

 

New Reactions and Methodology, Total Synthesis, Materials, Devices and Switches, Lipids, Nucleotides and Mimetics
8:00 PM-10:00 PM, Tuesday, March 27, 2007 Hyatt Regency Chicago -- Riverside Center, Poster

Division of Organic Chemistry

The 233rd ACS National Meeting, Chicago, IL, March 25-29, 2007