ORGN 485 |
| Our group has recently developed a novel copper(II)-catalyzed oxaziridine-mediated aminohydroxylation of alkenes. In this presentation, we describe the extension of our methodology to electron-rich aromatic heterocycles. Aminohydroxylation of benzofuran, for example, proceeds in 82% yield to give a single regioisomeric aminal product. The full scope of aminohydroxylation reaction of furan derivatives will be presented. Development of this methodology would offer rapid synthetic access to biologically important molecules such as aminonucleosides.
|
|
New Reactions and Methodology, Total Synthesis, Materials, Devices and Switches, Lipids, Nucleotides and Mimetics
8:00 PM-10:00 PM, Tuesday, March 27, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |
