ORGN 678 |
| The absolute configurations of erythro- and threo- diols, amino alcohols and diamines were successfully determined using a highly fluorinated zinc porphyrin tweezer via newly developed chiroptical protocol based on Exciton Coupled Circular Dichroism (ECCD). This novel zinc tweezer host demonstrated good binding affinity with hydroxyl groups due to the greatly enhanced Lewis acidity, thus facilitating the straightforward stereochemical assignment of chiral diols without any derivatization. This method enables the stereochemical determination of erythro diols, which has been problematic via other methodologies. Correlation of the observed CD couplet with the absolute configurations will be presented. |
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Asymmetric Reactions, Combinatorial Chemistry, Molecular Recognition and Self-Assembly, Proteins, Peptides, Amino Acids and Enzyme Inhibitors
8:00 PM-10:00 PM, Wednesday, March 28, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Sci-Mix
Division of Organic Chemistry |