ORGN 420 |
| spirastrellolide A was shown to exhibit potent inhibitory activity against protein phosphatase 2A (IC50 = 1 nM) along with a good selectivity for PP2A over PP1. We became interested in spirastrellolide A as a result of our recent interest and efforts in developing an unconventional approach to the synthesis of spiroketals. In our previous research, the synthesis of the C11-C23 fragment was performed by the acid-promoted ketal formation and the the ketal-tethered RCM strategy. Therefore, we planned to approach C1-C23 fragment with our prowess main step as the application to feature a ketal-tethered RCM strategy for constructing of spiroketals.
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New Reactions and Methodology, Total Synthesis, Materials, Devices and Switches, Lipids, Nucleotides and Mimetics
8:00 PM-10:00 PM, Tuesday, March 27, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |
