ORGN 705 |
| Guanosine forms supramolecular structures known as G-quadruplexes in which four gua-nine bases form a tetrad and two or more of such tetrads stack using a metal cation like potassium as a template. Recently, we showed that lipophilic 8-aryl-2'-deoxyguanosine derivatives (8ArGs) can also form quadruplexes in organic media and that the 8-aryl group could be used to modulate the supramolecular properties of the resulting assembly. On the other hand, little is known of the self-assembly of hydrophilic 8ArGs in aqueous environments. We will discuss a general method for the synthesis of such 8ArGs as well as their characterization of the supramolecular properties in aqueous media by spectro-scopic methods (NMR, UV and CD).
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Asymmetric Reactions, Combinatorial Chemistry, Molecular Recognition and Self-Assembly, Proteins, Peptides, Amino Acids and Enzyme Inhibitors
8:00 PM-10:00 PM, Wednesday, March 28, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |
