Progress toward the total synthesis of the bisindole alkaloid angusticraline: Emphasis on the northern hemisphere as well as the total synthesis of other monomeric indole alkaloids

ORGN 418

Chitra R Edwankar, csawant@uwm.edu, Department of Chemistry and Biochemistry, University of Wisconsin Milwaukee, 3210, N.Cramer Street, Milwaukee, WI 53210, Rahul Edwankar, EDWANKAR@UWM.EDU, Department of Chemistry, University of Wisconsin-Milwaukee, 3210 N Cramer St, Chem Bldg 144, Milwaukee, WI 53211, and James M. Cook, capncook@uwm.edu, Department of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, 3210 N. Cramer Street, Milwaukee, WI 53211.
Angusticraline 1 is a dimeric indole alkaloid composed of a methoxy macroline indole unit coupled to cabucraline, which is an akuammiline related indole alkaloid. Progress towards the total synthesis of the northern hemisphere of 1, as well as other alkaloids which belong to the sarpagine series will be presented.

 

New Reactions and Methodology, Total Synthesis, Materials, Devices and Switches, Lipids, Nucleotides and Mimetics
8:00 PM-10:00 PM, Tuesday, March 27, 2007 Hyatt Regency Chicago -- Riverside Center, Poster

Division of Organic Chemistry

The 233rd ACS National Meeting, Chicago, IL, March 25-29, 2007