ORGN 400 |
| The process of atherosclerosis or the buildup of cholesterol in the arteries is the cause of major diseases such as strokes, heart attacks other heart diseases. This process is therefore the root cause of the number one killer in the Western world. Imaging of the atherosclerotic plaque is therefore a topic of great current interest. The helical, amphiphatic peptide 37pA has been shown to be an efficient mimic for the lipoprotein ApoA-I, which is a key constituent of HDL. Previously, HDL has been recombined with gadolinium containing phospholipids and the nanoparticles thus formed have been shown to be efficient contrast agents for the imaging of atherosclerotic plaques in mice (JACS 2004, 126, 16316). Herein we report the constitution of wholly synthetic HDL mimicking nano-discs from 37pA and phospholipids, which incorporate gadolinium. The properties of these discs as MRI contrast agents have been investigated via in vivo studies.
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New Reactions and Methodology, Total Synthesis, Materials, Devices and Switches, Lipids, Nucleotides and Mimetics
8:00 PM-10:00 PM, Tuesday, March 27, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |
