ORGN 610 |
| A urea of 7-deazaguanine (DeUG, 1), a high-affinity quadruply hydrogen-bonding module complement to 2,7-diamido-1,8-naphthyridine (DAN, 2), has been synthesized bearing functionality that facilitates covalent incorporation into a wide range of materials via the Huisgen 1,3-dipolar cycloaddition (“click”) reaction. DeUG was designed as a robust analogue of our recently reported urea of guanosine (UG). The design, synthesis and complexation behavior of DeUG will be presented. Additionally, DeUG has been attached to a variety of silica surfaces using the click methodology. The self-assembly of DAN analogues on these surfaces will also be presented.
|
|
Molecular Recognition and Self-Assembly
1:00 PM-5:00 PM, Wednesday, March 28, 2007 McCormick Place Lakeside -- Room E352, Level 3, Oral
Division of Organic Chemistry |
