Automated iterative solution-phase synthesis and its application to glycomics

ORGN 537

Nicola L. Pohl, npohl@iastate.edu, Department of Chemistry and the Plant Sciences Institute, Iowa State University, Gilman, Ames, IA 50011
Automated solid-phase synthesis of nucleic acids and peptides has driven a significant part of genomics and proteomics studies. Unfortunately, solid-phase approaches usually require large excesses of building blocks to achieve the high yields required when intermediates cannot be purified and therefore are practically limited to building blocks that are made in a few steps. This talk will discuss an alternative solution-phase automation strategy to iterative synthesis. The automated synthesis of a range of oligosaccharides for glycomics will be discussed.