ORGN 487 |
| In continuation of our studies on the development of novel methods for the synthesis of heterocycles we found that phosphatyloxy-substituted alkynyl ketones 1 and imines 2 undergo facile Cu-catalyzed cycloisomerization reaction with concomitant 1,3-migration of phosphatyloxy group to form furans 3 and indolizines 4 in good yield. It was also found that phosphatyloxy heterocycles 3 and 4 can be efficiently functionalized via Kumada cross-coupling protocol to give alkyl- and aryl-substituted derivatives 5 and 6, respectively.
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New Reactions and Methodology, Total Synthesis, Materials, Devices and Switches, Lipids, Nucleotides and Mimetics
8:00 PM-10:00 PM, Tuesday, March 27, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |
