ORGN 611 |
| Numerous anion receptors and sensors utilizing hydrogen bonding have been synthesized. However, only few of these are capable of sensing anions in aqueous solutions as the solvating water competes effectively for anion-hydrogen bonding, which makes reliable sensing of anions difficult. Recently, we described calix[4]pyrrole isomers 3-6 as potential sensors for anions that use hydrogen bonds to form the anion-receptor complex. To be able to use 3-6 for sensing of aqueous anions, we embedded those sensors 3-6 in a hydrogel matrix. Hydrogel matrices internalize the bulk water and partially strip the hydrate molecules off the anions thus making the anions easier to be recognized and bound. The resulting hydrogel-calixpyrrole sensors 3-6 are able to bind the naked anions and undergo a change in color, which is then used as a signal output. Deposition of the sensor hydrogels into multi-well chips allows for fabrication of colorimetric arrays.
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Molecular Recognition and Self-Assembly
1:00 PM-5:00 PM, Wednesday, March 28, 2007 McCormick Place Lakeside -- Room E352, Level 3, Oral
Division of Organic Chemistry |
