Titanium mediated conversion of allyl alcohols to secondary allylic amines

ORGN 592

Bala Ramanathan, balasub@cem.msu.edu and Aaron L. Odom, odom@cem.msu.edu. Department of Chemistry, Michigan State University, East Lansing, MI 48824
A novel methodology for C–N bond formation involving allyl alcohols to generate secondary allylic amines will be presented. Substituent effects on the allyl alcohol will be examined through a library of compounds. Reaction between a homoallylic alcohol and cyclohexylamine yields a spiro amine. Deuterium labeling studies on both allyl alcohol and homoallylic alcohol reactions will be examined to investigate the mechanism.
 

Metal-Mediated Reactions and Syntheses
1:00 PM-4:20 PM, Wednesday, March 28, 2007 McCormick Place Lakeside -- Room E350, Level 3, Oral

Division of Organic Chemistry

The 233rd ACS National Meeting, Chicago, IL, March 25-29, 2007