ORGN 628 |
| Rhamnogalacturonan I (RG I) is an important component of pectin, a complex family of plant primary cell wall polysaccharides. Pectins have roles in plant growth, development and disease resistance and are used as gelling agents in the food industry and coatings in medical devices. However, little is known about the biosynthesis of RG I and its specific molecular interactions; well-defined structures are difficult to isolate from heterogeneous natural sources. To access specific molecular fragments for such studies, we have developed a flexible strategy to access a range of RG I structures from five different rhamnose and galactose building blocks. These building blocks serve as inputs for a new fluorous-tag-based automated protocol for the iterative solution-phase synthesis of a discrete library of rhamnogalacturonan I fragments. |
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Asymmetric Reactions, Combinatorial Chemistry, Molecular Recognition and Self-Assembly, Proteins, Peptides, Amino Acids and Enzyme Inhibitors
8:00 PM-10:00 PM, Wednesday, March 28, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |