Alcohols can be readily oxidized via hydride transfer by NAD⁺ coenzyme catalyzed by alcohol deydrogenases that contain a Zn(II) ion in the active site. We report our recent study of the hydride reduction of a NAD⁺ model N-methylacridinium ion (MA⁺ClO₄^-) by isopropanol at reflux conditions in the presence of five different Zn(II) species, Zn(ClO₄)₂•6H₂O, Zn(OTf)₂, Zn(NO₃)₂, Zn(OC(O)CH₃)₂ and a complex [(TACD)-Zn-OH₂](ClO₄)₂ (TACD=1,4,7,10-tetraazacyclododecane). Isolated yields of the acid-stable product of N-methylacridan (MAH) as high as 71% were observed with increasing the concentrations of the Zn(II) catalysts. In the absence of the Zn(II) catalyst, the reaction of MA⁺ salts of perchlorate and iodide gave rise to MAH with 7% and 40% yields, respectively. KOTf and KI were also found to catalyze the reaction. The results suggest that in the reactions studied both Zn(II) and negatively charged counter ions catalyze the reaction.