ORGN 656 |
| The Didemnaketal A and B (1a,b) inhibit HIV protease with IC50s of 2 mM and 10 mM, respectively, and are early examples of HIV protease inhibitors that lack nitrogen. In the course of determining the key portion of these compounds that inhibits the protease, we have identified that the pentaester subunit inhibits the HIV-1 protease (see, Fan, X., et al, J. Am. Chem. Soc. 1998, 120, 8893). We then synthesized a series of pentaester analogs 2 and 3 of Didemnaketals. Synthetic efforts and structure activity studies of these compounds (2-3) will be presented.
|
|
Asymmetric Reactions, Combinatorial Chemistry, Molecular Recognition and Self-Assembly, Proteins, Peptides, Amino Acids and Enzyme Inhibitors
8:00 PM-10:00 PM, Wednesday, March 28, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |
