ORGN 615 |
| Transport of anions across lipid bilayers typically occurs by one of two mechanisms; a carrier mechanism where a transport molecule binds the anion of interest and the complex diffuses through the membrane, or a channel mechanism where the transport molecule incorporates into the membrane allowing the flow of ions from one side of the bilayer to the other. Recently, we synthesized a series of phosphatidylcholine derivatives that were found to have chloride transport capabilities. Upon closer evaluation we found these transporters follow a new mechanism of anion transport where the anion is relayed from one leaflet of the bilayer membrane to the other. In this presentation the synthesis of the transporter molecules as well as chloride transport data will be presented.
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Molecular Recognition and Self-Assembly
1:00 PM-5:00 PM, Wednesday, March 28, 2007 McCormick Place Lakeside -- Room E352, Level 3, Oral
Division of Organic Chemistry |
