ORGN 550 |
| Several ongoing total synthesis projects in our group utilize strategies that are premised on proposed biosynthetic proposals. Ideally, these proposals delineate strategic bond disconnections and reorganizations but may or may not be related to what is being done by the organisms from which these natural products are derived. In most cases, the biosynthesis of these natural products have not been fully delineated however reasonable biosynthetic proposals provide an instructive means to generate efficient routes to the target molecules. Selected studies from our ongoing work towards oroidin alkaloids and beta-lactone containing proteasome inhibitors will serve to illustrate this strategy. |
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Biomimetic Natural and Unnatural Products Synthesis
8:30 AM-11:55 AM, Wednesday, March 28, 2007 McCormick Place Lakeside -- Room E350, Level 3, Oral
Division of Organic Chemistry |