ORGN 156 |
| Commercially available Schrock's catalyst was used to catalyze ring closing and cross metathesis reactions using 1-butyl-3-methylimidazolium hexafluorophosphate (room temperature ionic liquid or RTIL) as solvent. Reactions proceeded with 9-15 mole % catalyst in 22-72 hours at 75 °C. This RTIL is an interesting new, green solvent for the temperature, water, and air sensitive Schrock's catalyst and leads to approximately 100% conversion by 1H NMR for substrates containing various functional groups. We will report a new method to separate small molecules from this RTIL using a polydimethylsiloxane (PDMS) membrane. A Soxhlet extraction was performed with refluxing methanol for a period of 6 days and we isolated 66-86% of small molecules devoid of RTIL. The use of PDMS thimbles for separation of RTIL from small molecules is an exciting new method for removal of RTIL from reaction mixtures.
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Process R&D, Physical Organic Chemistry, Heterocycles, Aromatics, Metal-Mediated Reactions
8:00 PM-10:00 PM, Sunday, March 25, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Sci-Mix
Division of Organic Chemistry |
