ORGN 413 |
| N-Methylwelwitindolinone C Isothiocyanate (1) was isolated in 1994 from the blue green algae H. welwitschii and has been shown to reverse P-glycoprotein mediated multi-drug resistance and to induce microtubule depolymerization. Compound 1 is also a unique bicyclo [4.3.1] decanone composed of an oxindole and a densely functionalized cyclohexanone linked through a 7-membered ring. A highly regio and stereoselective Diels Alder reaction was used to construct a highly elaborated AD ring system. These results, along with progress toward the closure of the BC ring, will be presented.
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New Reactions and Methodology, Total Synthesis, Materials, Devices and Switches, Lipids, Nucleotides and Mimetics
8:00 PM-10:00 PM, Tuesday, March 27, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |
