ORGN 425 |
| A synthetic approach to 1a, proposed by Fukuyama to be the active form of FR900482, and 1b, the proposed active form of semi-synthetic derivative FK317, will be described. A key step is the early installation of the labile aziridine through coupling of 2 and 3. Subsequent tin-lithium exchange and intramolecular Michael addition provides tetracycle 4. The difficult removal of the N-trityl group is accomplished without loss of the labile aziridine functionality to provide advanced intermediate 5. Studies toward the completion of the synthesis will be discussed.
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New Reactions and Methodology, Total Synthesis, Materials, Devices and Switches, Lipids, Nucleotides and Mimetics
8:00 PM-10:00 PM, Tuesday, March 27, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |
