Synthesis, NMR characterization and supramolecular structure of coumarins derivatives

ORGN 710

Rocio Santos, rocio_jael@ucol.mx1, Ana Peraza, alperaza59@hotmail.com1, Itzia Padilla, itzia20042000@yahoo.com.mx2, Efrén García, efren1003@yahoo.com.mx2, and Francisco Martínez1. (1) Departamento de Química, Universidad de Colima, km 9 Colima-Coquimatlán, Coquimatlán -Colima, 28400, Mexico, (2) Departamento de Química UPIBI, Instituto Politécnico Nacional, Av. Acueducto s/n, México, 07340, Mexico
Utilizing a simple methodology between diethyl malonate and different salicilaldehydes, the corresponding coumarin 3-ethyl carboxylates were formed. These Compounds were condensed with ethanolamine and amine propyl morpholine to form the amide derivatives whose structural characterization by 1 H and 13C NMR is discussed.The study includes the X-ray difraction with emphasis in the supramolecular structure, these compounds are self assembled in hydrogen-bonded layers among other common features, as shown in the figure. In summary, The development of a a simple methodology for the preparation of coumarin derivatives and the study of their molecular and supramolecular structure are reported.

 

Asymmetric Reactions, Combinatorial Chemistry, Molecular Recognition and Self-Assembly, Proteins, Peptides, Amino Acids and Enzyme Inhibitors
8:00 PM-10:00 PM, Wednesday, March 28, 2007 Hyatt Regency Chicago -- Riverside Center, Poster

Division of Organic Chemistry

The 233rd ACS National Meeting, Chicago, IL, March 25-29, 2007