ORGN 632 |
| This poster will report the development of synthetic ligands that can modulate cell-cell communication pathways in Gram-negative bacteria. The ability of bacteria to communicate with themselves and function as a group is central in both pathogenesis and symbiosis. Gram-negative bacteria communicate using small molecule signals and their cognate protein receptors to monitor their local population density in a phenomenon known as ‘quorum sensing'. The development of methods to attenuate bacterial quorum sensing represents a new anti-infective strategy. We have designed and synthesized a library of synthetic ligands using computational, synthetic organic, and combinatorial chemistry techniques. Evaluation of this library in a series of different Gram-negative reporter strains revealed a set of potent quorum sensing antagonists and agonists. This poster will present our on-going studies on these compounds, including pertinent in vitro and in vivo assays. |
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Asymmetric Reactions, Combinatorial Chemistry, Molecular Recognition and Self-Assembly, Proteins, Peptides, Amino Acids and Enzyme Inhibitors
8:00 PM-10:00 PM, Wednesday, March 28, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |