ORGN 269 |
| Optically active α-methyl α-amino acids are important building blocks for the synthesis of peptide, pharmaceutical and agrochemical compounds, in which the quaternary carbons show the effect on their conformations and biological activities. A new synthetic method for α-methyl-L-cysteine was realized by enzymatic resolution of racemic 2,4-dimethyl-4-methoxycarbonylthiazoline which can be derived from chloroacetone in 4 steps. Optically active 2,4-dimethyl-4-methoxycarbonylthiazoline was alternatively derived from α-methyl-L-serine as a starting material. In this presentation, a new enzymatic synthesis of α-methyl-L-serine will be also referred.
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Asymmetric Syntheis of α-Amino Acids: Novel Developments and Future Directions
1:00 PM-5:40 PM, Monday, March 26, 2007 McCormick Place Lakeside -- Room E350, Level 3, Oral
Division of Organic Chemistry |
