ORGN 646 |
| Cellular DNA can be modified by a variety of chemicals. These modifications can lead to the development of cancer. Almost all organisms have evolved DNA repair mechanisms. We develop reliable methods to trap, identify, and profile DNA damage proteins. We chemically synthesize a wide range of probes that mimic DNA damage and utilize them to trap proteins that recognize the damage. We identify the “fished out” proteins and characterize their function by in vivo and in vitro studies. This function-based proteomic method holds great promise for discovering new proteins that could provide targets for developing new cancer drugs. |
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Asymmetric Reactions, Combinatorial Chemistry, Molecular Recognition and Self-Assembly, Proteins, Peptides, Amino Acids and Enzyme Inhibitors
8:00 PM-10:00 PM, Wednesday, March 28, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Organic Chemistry |